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 COPD Support News Sept 24, 2010
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Carolyn-Mi
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608 Posts

Posted - Sep 24 2010 :  12:10:58 PM  Show Profile  Reply with Quote
Volume 10, Issue 43
September 24, 2010


AOL email users, please see the bottom of this newsletter for a special message.


COPD EXACERBATIONS
When used as a medical term, an "exacerbation" is, "An increase in the severity of a disease or in any of its signs or symptoms." Exacerbations can range from mild to severe or even acute, and are sometimes called "flare-ups." The above definition is from the "TheFreeDictionary's" medical dictionary that can be found at:
http://medical-dictionary.thefreedictionary.com/exacerbation


CAUSES OF EXACERBATIONS
An abstract of an article in "Chest" the journal of the American College of Chest Physicians, discusses exacerbations and their causes that include:
*Viral Infections
*Bacterial Infections
*Inhalation of environmental irritants
*Bronchiolitis (exudativa) (inflammation of tiny airways)
*Small airway mucosa hyperemia (no brief definition attempted)
*Discontinuation of medications
*Deviation from diet
For more information on exacerbations and their causes, please see the full abstract at:
http://chestjournal.chestpubs.org/content/117/5_suppl_2/376S.full


SUSCEPTIBILITY TO EXACERBATIONS IN COPD
This week, the "New England Journal of Medicine," published the results of their three-year long study designed to better understand the underlying mechanisms of COPD exacerbations. The study, entitled "ECLIPSE" (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points) found that having a history of exacerbations is the best predictor of the probability of having them in the future. Whereas it appears that some people have a resistance to exacerbations, others, they say, are inherently more prone to them, with some individuals having them frequently and continuously. The researchers also report that exacerbations become more common as COPD progresses. The findings of this study lead researchers to believe there might be an underlying variable such as genetics, biology or a behavioral mechanism involved that determines individuals' susceptibility to exacerbations. For the abstract, please visit:
http://www.nejm.org/doi/full/10.1056/NEJMoa0909883
For a fuller discussion, see:
http://tinyurl.com/25hhkje


EXACERBATIONS IN COPD: ONE THING LEADS TO ANOTHER
An earlier article (2009) from "ScienceDaily" reports similar patterns concerning the predictability of exacerbations. However, they take it one step further; by pointing out the consequence of exacerbations by stating, "New research shows that individual exacerbations in chronic obstructive lung disease (COPD) themselves increase the likelihood of repeat exacerbations, even after five days of full, asymptomatic recovery—badd news for patients with COPD, where each exacerbation can drive the progression of the disease." The full article can be found at:
http://tinyurl.com/27zz8zn


DETECTING EXACERBATIONS USING THE CLINICAL COPD QUESTIONNAIRE
An abstract in the "Health and Quality of Life Outcomes," (Biomed Central) reports the development of a new questionnaire to detect exacerbations that would ordinarily go unreported. Although more studies are needed to determine the questionnaire's validity and practicality, the use of a weekly report, they believe, might be a "low burden" way to detect unreported exacerbations, and therefore provide earlier and more appropriate treatment.
http://www.hqlo.com/content/8/1/102


ALSO IN THIS ISSUE
- DAXAS (ROFLUMILAST) DATA ANALYSIS SHOWS REDUCTION IN HARMFUL LUNG ATTACKS
- CARDIOVASCULAR RISK FACTOR AND COPD
- STUDY SHOWS ONBREZ BREEZHALER IS BETTER THAN SALMETEROL IN REDUCING SHORTNESS OF BREATH
- MEDICARE TO EXPERIMENT WITH EXPANSION OF HOSPICE CARE
- UNDERSTANDING PALLIATIVE CARE
- FOOD AND DRUG ADMINISTRATION FUNDS CONTINUED STUDIES INTO AAT DEFICIENCY (INHERITED EMPHYSEMA)
- HAND DRYING
- GUM DISEASE AND RESPIRATORY DISEASES
- WORKING WHILE SICK? STUDY FINDS EVEN DOCTORS DO IT
- POSSIBLE NEW COPD MEDICATION ACLIDINIUM BROMIDE FOUND EFFECTIVE AND WELL TOLERATED IN PATIENTS WITH COPD
- MISCELLANEOUS
GOOD AND BAD HABITS
FREE AUDIO BOOKS
ONLINE COUPONS
IS AN ONLINE CHECKING ACCOUNT FOR YOU?
QUIZZES GALORE
SPECIAL NOTE FOR AOL EMAIL USERS


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SOURCES: News items summarized in The COPD-NEWS are taken from secondary sources believed to be reliable. However, the COPD Family of Services does not verify their accuracy.
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DAXAS (ROFLUMILAST) DATA ANALYSIS SHOWS REDUCTION IN HARMFUL LUNG ATTACKS
There seems to be something in the news each week about Daxas (roflumilast), and this week it is reported that a study conducted in 14 different countries finds that the long-term impact of exacerbations is seriously underestimated. The study was sponsored by a research grant from the Daxas manufacturer Nycomed. The results of the study coincides with the European Respiratory Society (ERS) Congress, 2010, held in Barcelona, where new data were also presented concerning the impact the medication Daxas has on decreasing the frequency of exacerbations. Daxas is a once a day oral medication for COPD that has been approved in the European Union and other countries, however is not yet available in the United States.
http://tinyurl.com/243cknu


CARDIOVASCULAR RISK FACTOR AND COPD
The National Institute of Health's National Heart Lung and Blood Institute points out, "Cardiovascular disease plays a major role in COPD, being responsible for the death of more than 30% of these patients." The importance of the heart-lung connection is explained further at:
http://tinyurl.com/22pb697


One of the cardiovascular risk factors we have some control over is cholesterol level. One study's results, published in "Cell Metabolism" this month, reports what might be the discovery of why some genes cause some of us to have a greater chance of developing high cholesterol and suffering heart attacks than others. Researchers are a step closer to understanding how LDL (bad cholesterol) is released from the liver into the bloodstream. Although they point out that 95% of cardiovascular disease is a result of environmental factors modified by genes, they also know that there are some people who eat high fat diets, who are overweight and who do not have cardiovascular disease. This phenomenon suggests there is an important genetic factor involved. The complete article can be found at:
http://tinyurl.com/29uon7v


STUDY SHOWS ONBREZ BREEZHALER IS BETTER THAN SALMETEROL IN REDUCING SHORTNESS OF BREATH
The manufacturer Novartis has released the results of their study demonstrating that their once-daily Onbrez Breezhaler (indacaterol) is significantly better at improving lung function than Serevent (salmeterol) for people with COPD. Read all about it at:
http://www.webwire.com/ViewPressRel.asp?aId=123469


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COMMERCIAL FREE: We do not accept any paid advertising. Any corporations, products, medicines (prescription or over the counter) mentioned in this newsletter are for informational purposes only and not to be construed as an endorsement or condemnation of same.
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MEDICARE TO EXPERIMENT WITH EXPANSION OF HOSPICE CARE
Confusion, politics, surveys, polls, rhetoric, and panels aside regarding proposed end of life care under Medicare, Medicare is moving ahead to experiment at 15 sites nationwide with a new hospice-like program design. Although hospice care is already covered by Medicare (as long as qualifying conditions are met), recipients must forgo live-prolonging medical interventions and treatments in order to participate. Medicare has announced it will conduct demonstration projects at the 15 sites that will allow "concurrent care" ­ care that allows both hospice as well as actiive treatment care. Read more about this at:
http://tinyurl.com/38nkbdw


UNDERSTANDING PALLIATIVE CARE
Mike Howerton, from Oshkosh, Wisconsin, recommends this Mayo Clinic article on palliative care, a topic closely related to and often confused with hospice care. According to the Mayo Clinic, "Palliative care aims to improve quality of life for people who have advanced illnesses, as well as their families. Palliative care also takes into account the emotional, physical and spiritual needs and goals of the person who's being treated and his or her family. Palliative care doesn't replace primary medical treatment. Instead, palliative care is provided in conjunction with all other medical treatment." The entire article can be found at:
http://www.mayoclinic.com/health/palliative-care/MY01051


FOOD AND DRUG ADMINISTRATION FUNDS CONTINUED STUDIES INTO AAT DEFICIENCY (INHERITED EMPHYSEMA)
A privately-held company, Applied Genetic Technologies Corporation, announces that the Food and Drug Administration's Orphan Drug Program, has given them a $1 million dollar grant to fund a phase II clinical trial evaluating the safety and effectiveness of a new treatment for Alpha 1 Antitrypsin Deficiency (AATD), a genetic disease known to result in serious lung and/or liver disease. ATT deficiency is often called genetically inherited emphysema. FDA's Orphan Drug Program focuses specifically on the development of treatments for rare diseases and conditions. More information can be found at:
http://tinyurl.com/2g9utqe


HAND DRYING
Hand sanitizers and hand washing aside, how you dry your hands is also important in removing bacteria. Your hand-drying options include paper towels, traditional hot air hand dryers, and a new type of dryer that uses high velocity air jets. Your method is also important. A study published in the "Journal of Microbiology" found that the hands-down winner is paper towels. There's lots of other interesting information in their study, which you’ll find it at:
http://tinyurl.com/24j8ufg


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MEDICAL DECISIONS. Your physician should be consulted on all medical decisions. New procedures or drugs should not be started or stopped without such consultation. While we believe that our accumulated experience has value, and a unique perspective, you must accept it for what it is...the work of COPD patients. We vigorously encourage individuals with COPD to take an active part in the management of their disease. They do this through education and by sharing information and thoughts with their primary physician and pulmonologist. However, medical decisions are based on complex medical principles and should be left to the medical practitioner who has been trained to diagnose and advise.
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GUM DISEASE AND RESPIRATORY DISEASES
Oral health is extremely important to those of us with COPD. Some bacterial respiratory infections are thought to be caused by inhaling fine droplets from the mouth and nose into the lungs, which for us are already compromised due to COPD. These droplets can contain bacteria, and gum disease is thought to be particularly dangerous. This article, on the American Academy of Periodontology's web site, provides information you can really sink your teeth into:
http://www.perio.org/consumer/mbc.respiratory.htm


WORKING WHILE SICK? STUDY FINDS EVEN DOCTORS DO IT
Lindsey Tanner, Associated Press medical writer, penned an interesting article picked up by Yahoo News that reports that the majority (58 percent) of medical residents reported that they worked at least once when sick, and 31 percent said they worked more than once while sick. For the complete article, please see:
http://tinyurl.com/2627luq


POSSIBLE NEW COPD MEDICATION ACLIDINIUM BROMIDE FOUND EFFECTIVE AND WELL TOLERATED IN PATIENTS WITH COPD
New research was presented at the European Respiratory Society’s 2010 Congress this week that suggests a new medication being studied, aclidinium bromide, is safe and significantly improves lung function. This medication, given twice a day in an inhaler, is in the same class of drugs as tiotripium (Spiriva). Research into this medication continues. For more information, please see:
http://tinyurl.com/2ew8jh2


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JOIN US? Subscription to this Newsletter is free and we hope that it serves your needs. For more Newsletter information, go to: http://copd-support.com/signup-news.html


The Newsletter, like all the other endeavors of the Family of COPD Support Programs, is provided to you by COPD-Support, Inc. a non-profit member organization with IRS designation 501(c)(3). If you would like to be involved and help us provide these programs to the individuals who benefit from them, please consider joining us as a member. Further information is available at:http://copd-support.com/membership.html" target="_blank"> http://copd-support.com/membership.html
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MISCELLANEOUS


GOOD AND BAD HABITS
John Windhorst, from Minnesota, shares something he's learned that might encourage others who embark upon making significant changes, such as starting a new exercise program. He points out that change often involves replacing old habits with new ones, so it is important to keep in mind that:


* It takes 6 weeks to get something new going in your life


* It takes yet another 6 weeks to make the change into a habit


That's 3 months of doing something daily before it is really part of your life! If there is a secret to making significant changes in your life, perhaps the key is learning to be patient, and giving yourself time to change habits.


FREE AUDIO BOOKS
Jack Stewart, from Tampa, Florida would like to share this site with others who might be interested in free audio books:
http://www.podiobooks.com/


ONLINE COUPONS
Are you afraid of online coupons? This article in "DollarStretcher" provides useful information that might save you a few bucks:
http://tinyurl.com/2dfo3od


IS AN ONLINE CHECKING ACCOUNT FOR YOU?
This site discusses the pros and cons of online checking accounts:
http://tinyurl.com/29vq44z
http://tinyurl.com/29vq44z



QUIZZES GALORE
This site has a quiz for just about everything: funny quizzes, love quizzes, IQ quizzes and even personality quizzes. Go quiz yourself at:
http://www.quizrocket.com/


SPECIAL NOTE FOR AOL EMAIL USERS
You can get your newsletter with active hyperlinks if you access your AOL mail through the web. If you are an AOL email user and use the AOL software to access your email newsletter, you will notice that the hyperlinks in the newsletter don't work, and they are not underlined and they are not in blue print. You might have had to cut and paste the links into your browser in order to visit the web sites provided. There is an easy solution to this problem: Rather than retrieving your mail the regular way, just go to www.aol.com. You can sign in there to retrieve your email and you will find that the hyperlinks work. They will be underlined and in blue. If you click on them, they will take you to the article being referenced. Even if you are already signed on to AOL, you can go to www.aol.com and sign in to get your mail with active hyperlinks!


For comments and questions, or to contact Richard D. Martin, please send your email to: newsletter@COPD-Support.com


Until next Friday,


Richard D. Martin, Editor


Web version of the News: http://copd-support.com/news.html
Archives at: http://home.ease.lsoft.com/archives/copd-news.html


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To see other programs provided in the Family of COPD Support
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http://home.ease.lsoft.com/scripts/wa.exe?SUBED1=copd-news&A=1


Please keep in mind that all posts are from COPD patients / caregivers
and not medically trained professionals - consult your medical team
for your personal medical needs.
**********************************************************************

COPD Support
http://www.copd-support.com
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